Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy
نویسندگان
چکیده
منابع مشابه
Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy
Amino acids, leucine in particular, are known to inhibit autophagy, at least in part by their ability to stimulate MTOR-mediated signaling. Evidence is presented showing that glutamate dehydrogenase, the central enzyme in amino acid catabolism, contributes to leucine sensing in the regulation of autophagy. The data suggest a dual mechanism by which glutamate dehydrogenase activity modulates aut...
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ژورنال
عنوان ژورنال: Autophagy
سال: 2013
ISSN: 1554-8627,1554-8635
DOI: 10.4161/auto.24083